High membrane expression of CD163 by bone marrow cells is not a specific marker of macrophage activation syndrome (MAS)
نویسندگان
چکیده
Background MAS is a life-threatening complication seen predominantly in children with SoJIA, often difficult to recognize because specific diagnostic criteria for MAS have not yet been devised. MAS is characterized by an overwhelming inflammatory reaction driven by excessive T cell expansion and hemophagocytic macrophages. Preliminary studies suggest that high sIL-2R α serum levels and sCD163 might be useful as diagnostic markers for MAS. This study assesses the expression of CD163 and CD68 in bone marrow cells of patients with MAS and especially in those with SoJIA who developed MAS.
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